Targeting Terrorists More Effectively Act of 2005 - Sets forth provisions with respect to: (1) Army special operations forces increases; (2) increasing foreign language expertise in the United States for the purpose of improving national security; (3) preventing terrorist financing; (4) prohibiting transactions with countries that support terrorism; (5) preventing the growth of radical Islamic fundamentalism, and promoting democracy and development in the Middle East, Central Asia, South Asia, and Southeast Asia; (6) advancing U.S. interests through diplomacy; (7) the treatment of detainees, including establishment of a National Commission to Review Policy Regarding the Treatment of Detainees; (8) strategy for the U.S. relationship with Afghanistan, Pakistan, and Saudi Arabia; (9) non-proliferation programs, including Russian nuclear facilities and tactical nuclear weapons; (10) border protection, including border personnel increases; (11) seaport protection, including deployment of radiation detection portal equipment, tanker security, and acceleration of the Megaports Initiative; (12) first responders, including training for law enforcement personnel; and (13) prohibitions on war profiteering.