Prekindergarten-Oriented Professional Support Act of 2005 - Authorizes the Secretary of Education to make grants to states and local educational agencies to: (1) pay all or a portion of the salaries, benefits, and training costs of new prekindergarten teachers at prekindergarten providers; and (2) increase retention of prekindergarten teachers by establishing a career ladder for them.
Makes high-quality state, local, or private nonprofit or for-profit prekindergarten providers eligible for the new teacher program if they: (1) meet standards issued by the Secretary; (2) serve a significant percentage of low-income children; and (3) if private and tuition-based, agree to ensure that at least one-half of the children served by new teachers will be low-income.