Thorium Energy Independence and Security Act of 2008 - Amends the Atomic Energy Act of 1954 to direct the Secretary of Energy to establish, and provide funds to, an office for the regulation of thorium fuel cycle nuclear power generation in each of: (1) the Office of Nuclear Energy, Science and Technology (ONEST) of the Department of Energy; and (2) the Nuclear Regulatory Commission (NRC).
Directs the NRC Chairman to promulgate regulations for facilities and materials used in thorium fuel cycle nuclear power generation.
Requires the heads of the two Offices to: (1) implement demonstration projects for thorium fuel cycle nuclear power generation at the Idaho National Engineering Laboratory; and (2) recommend to the Secretary methods of strengthening international partnerships to advance nuclear nonproliferation through thorium fuel cycle nuclear power generation, and of providing incentives to nuclear reactor operators to use proliferation-resistant, low-waste thorium fuels in lieu of other fuels.