Blue Collar Computing and Business Assistance Act of 2006 - Directs the Under Secretary of Technology of the Department of Commerce to award grants to establish up to five Advanced Multidisciplinary Computing Software Centers at eligible entities (any nonprofit, consortia of nonprofits, or partnership between a for-profit and a nonprofit) throughout the United States.
Requires each Center to conduct: (1) general outreach to small businesses and manufacturers in all industry sectors within a geographic region assigned by the Under Secretary; and (2) technology transfer, development, and utilization programs related to a specific industry sector for all firms in that sector nationwide.