Native American Small Business Assistance and Entrepreneurial Growth Act of 2010 - Amends the Small Business Act to establish within the Small Business Administration (SBA) the Office of Native American Affairs, headed by an Associate Administrator, to implement SBA programs for the development of business enterprises by Native Americans. Requires the Office to assist Native American entrepreneurs to: (1) develop small businesses; (2) develop management and technical skills; (3) seek federal procurement opportunities; (4) increase Native American employment opportunities; and (5) increase Native American access to capital markets.
Requires: (1) SBA to provide financial assistance to tribal colleges, certain nonprofit organizations, and small business development or women's business centers to create Native American business centers; (2) each business center to conduct five-year projects for business education aid to such entities; and (3) each assistance applicant to submit a five-year plan on proposed assistance and training activities.