Great Lakes Restoration Semipostal Stamp Act of 2010 - Requires the United States Postal Service to issue and sell, at a premium, a Great Lakes Restoration Semipostal Stamp.
Requires proceeds from the sale of such stamp to be transferred to the Environmental Protection Agency (EPA) for the operations of the Great Lakes Restoration Initiative. Prohibits such proceeds from being taken into account in any decision relating to the level of appropriations or other federal funding to be furnished to the EPA or such Initiative.
Requires the stamp to: (1) be made available to the public for at least five years; and (2) depict images of the five Great Lakes.