Help Small Businesses Start and Grow Act of 2010 - Amends the Internal Revenue Code to: (1) allow an increased tax deduction for business start-up expenditures in 2009, 2010, or 2011; (2) allow a standard tax deduction for the business use of a home; (3) increase the rate of the tax deduction for business meals and entertainment expenses; and (4) extend bonus depreciation allowances through 2012.
Directs the Administrator of the Small Business Administration (SBA) to: (1) establish and carry out a small business direct lending program; (2) report to the House and Senate Small Business Committees on the loan program, including the number and amount of loans made under the program. Requires the Comptroller General to evaluate the effectiveness of the program and identify any waste or abuse relating to the program.