Amends the Public Health Service Act to require the Director of the Agency for Healthcare Research and Quality (AHRQ) to make grants for research centers (each to be known as a Center for Clinical Discovery) to accelerate next-generation approaches to the development of new therapies and diagnostics by: (1) bringing together patients, researchers with specialized expertise, and sophisticated technologies; and (2) basing such development on individual genotypes and individual variations in cell and molecular physiology.