Requires the Director of such Center to: (1) administer grants to State and local public health entities to upgrade public health core capacities including surveillance, epidemiology, laboratory diagnosis, the workforce, and information systems; (2) manage and deploy when necessary the National Pharmaceutical Stockpile; (3) ensure States have Stockpile use plans; (4) establish and revise a list of biological, chemical, and radiological agents and toxins that could pose a severe threat to public health and safety; (5) regulate and track listed agents and toxins; (6) train and equip bioterrorism emergency response teams; (7) expand and improve the Laboratory Response Network; (8) organize and carry out simulation exercises; (9) develop and implement disease surveillance measures which include a nationwide electronic network; and (10) develop contingency response plans.