Classified Information Procedures Reform and Improvement Act of 2010 - Amends the Classified Information Procedures Act, with respect to the use and disclosure of classified information in legal proceedings, to: (1) allow ex parte pretrial conferences to protect national security; (2) expand protective orders to limit the use of or access to classified information; (3) expand discovery rules to restrict access to classified information, other than documents; (4) expand a defendant's notice requirement to include intent to use classified information; (5) establish additional standards for the admissibility, use, and disclosure of classified information at trial; (6) expand the interlocutory appeal rights of the United States; and (7) allow a court to fashion alternative procedures to prevent unnecessary disclosures of classified information at trial.