A bill to provide for the designation of the Devil's Staircase Wilderness Area in the State of Oregon, to designate segments of Wasson and Franklin Creeks in the State of Oregon as wild or recreation rivers, and for other purposes.

Devil's Staircase Wilderness Act of 2010 - Designates certain federal land in Oregon administered by the Forest Service and the Bureau of Land Management (BLM) as the Devil's Staircase Wilderness and as wilderness and a component of the National Wilderness Preservation System (NWPS).

Specifies this Act's effect on: (1) the jurisdiction and responsibilities of the state of Oregon with respect to fish and wildlife; (2) protective perimeters and buffer zones around the Wilderness; (3) activities and uses outside of the boundary of the Wilderness; and (4) treaty rights of Indian tribes.

Transfers the administrative jurisdiction over BLM land north of the Umpqua River to the Forest Service.

Amends the Wild and Scenic Rivers Act to designate Franklin and Wasson Creeks in Oregon as wild rivers and as components of the Wild and Scenic Rivers System.