Sand Creek Massacre National Historic Site Visitor Center Act of 2010 - Authorizes the Secretary of the Interior to enter into a cooperative agreement with Kiowa County, Colorado: (1) to assist in the renovation of the Murdock Building in Eads, Colorado; (2) for use of a part of the Murdock Building by the National Park Service (NPS) as the visitor center and administrative offices for the Sand Creek Massacre National Historic Site (the Park); and (3) to provide up to $650,000 to Kiowa County toward the cost of renovations and furnishing of the Murdock Building.
Sets forth a federal matching requirement. Requires the use of such federal funds for making improvements to, and installing furnishings within, those parts of the Murdock Building used by the Park. Prohibits the use of such funds to pay for personnel or other costs associated with the operation of the Murdock Building as a park visitor center.