Communities in Action Neighborhood Defense and Opportunity Act of 2008 or the CAN DO Act of 2008 - Directs the Attorney General, through the Office of Justice Programs of the Department of Justice (DOJ), to establish a five-year program of grants to six communities to establish and maintain pilot programs for Communities in Action Neighborhood Defense and Opportunity Centers (CAN DO Centers) to establish, administer, and coordinate: (1) the CAN DO Safer Streets Strategy Group Program and Guns off Our Streets Program; (2) the CAN DO Operation Community Patrol Program; (3) the CAN DO Street Monitoring Program; and (4) the CAN DO Services Providers Network.